منابع مشابه
Evolution of Coding Microsatellites in Primate Genomes
Microsatellites (SSRs) are highly susceptible to expansions and contractions. When located in a coding sequence, the insertion or the deletion of a single unit for a mono-, di-, tetra-, or penta(nucleotide)-SSR creates a frameshift. As a consequence, one would expect to find only very few of these SSRs in coding sequences because of their strong deleterious potential. Unexpectedly, genomes cont...
متن کاملEvolution of Base Substitution Gradients in Primate Mitochondrial Genomes
.........................................................................................vi CHAPTER 1. GENERAL INTRODUCTION....................................................1 CHAPTER 2. SURVEY OF LITERATURE...................................................17 CHAPTER 3. MATERIALS AND METHODS.................................................22 CHAPTER 4. RESULTS....................................
متن کاملEvolution of base-substitution gradients in primate mitochondrial genomes.
Inferences of phylogenies and dates of divergence rely on accurate modeling of evolutionary processes; they may be confounded by variation in substitution rates among sites and changes in evolutionary processes over time. In vertebrate mitochondrial genomes, substitution rates are affected by a gradient along the genome of the time spent being single-stranded during replication, and different t...
متن کاملFinding Alu in primate genomes with AF‐1
UNLABELLED Repetitive sequences occupy more than 40% of the human genome which is much larger compared to the 2% occupied by the coding DNA. Amongst these Alu elements are the second largest class of repeats, occupying nearly 10% of the whole genome. Alus have been implicated in many genomic processes, sometimes giving rise to aberrations while many times playing as silent player in genomic and...
متن کاملA Genome-Wide Landscape of Retrocopies in Primate Genomes
Gene duplication is a key factor contributing to phenotype diversity across and within species. Although the availability of complete genomes has led to the extensive study of genomic duplications, the dynamics and variability of gene duplications mediated by retrotransposition are not well understood. Here, we predict mRNA retrotransposition and use comparative genomics to investigate their or...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2011
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.2032